A Sensitive Assay for Unbound Docetaxel Using Ultrafiltration plus HPLC-MS and Its Application to a Clinical Study

A Sensitive Assay for Unbound Docetaxel Using Ultrafiltration plus HPLC-MS and Its Application to a Clinical Study

Introduction: Docetaxel, a taxane used in the treatment of solid tumours, exerts pharmacological activity when in its unbound form. We report a sensitive assay to quantify unbound docetaxel after oral administration of docetaxel plus encequidar (oDox+E). Unbound drug quantification is important due...

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Main Authors: David Wang (Author), Natalie Hughes-Medlicott (Author), Lilian Klingler (Author), Yi Wang (Author), Noelyn Hung (Author), Stephen Duffull (Author), Tak Hung (Author), Paul Glue (Author), Albert Qin (Author), Rudolf Kwan (Author), Wing-Kai Chan (Author), Christopher Jackson (Author)
Format: Book
Published: MDPI AG, 2024-04-01T00:00:00Z.
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