In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide
A series of N1,N3-bis (1-oxopropan-2-yl) isophthalamide-based derivatives 4-16 were prepared and their structures were confirmed by different spectral tools. The cytotoxic potentiality of novel compounds 4-16 was assessed by the MTT assay method on colon, lung and breast tumour cell lines. Compound...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Taylor & Francis Group,
2019-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_ae3a3224d3d242d68f95da0ad4e3d80d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Asmaa F. Kassem |e author |
| 700 | 1 | 0 | |a Gaber O. Moustafa |e author |
| 700 | 1 | 0 | |a Eman S. Nossier |e author |
| 700 | 1 | 0 | |a Hemat S. Khalaf |e author |
| 700 | 1 | 0 | |a Marwa M. Mounier |e author |
| 700 | 1 | 0 | |a Suliman A. Al-Yousef |e author |
| 700 | 1 | 0 | |a Sabry Y. Mahmoud |e author |
| 245 | 0 | 0 | |a In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide |
| 260 | |b Taylor & Francis Group, |c 2019-01-01T00:00:00Z. | ||
| 500 | |a 1475-6366 | ||
| 500 | |a 1475-6374 | ||
| 500 | |a 10.1080/14756366.2019.1613390 | ||
| 520 | |a A series of N1,N3-bis (1-oxopropan-2-yl) isophthalamide-based derivatives 4-16 were prepared and their structures were confirmed by different spectral tools. The cytotoxic potentiality of novel compounds 4-16 was assessed by the MTT assay method on colon, lung and breast tumour cell lines. Compound 5 gave the most significant specificity anticancer activity with safety response on normal cell lines. In vitro enzyme assay and several apoptotic parameters were examined to elucidate the mode of action of compound 5. Molecular docking studies also were simulated to put insight and give better understanding to its structural features. | ||
| 546 | |a EN | ||
| 690 | |a isophthalamide | ||
| 690 | |a amino acids | ||
| 690 | |a peptides | ||
| 690 | |a anticancer activity | ||
| 690 | |a molecular docking | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1247-1258 (2019) | |
| 787 | 0 | |n http://dx.doi.org/10.1080/14756366.2019.1613390 | |
| 787 | 0 | |n https://doaj.org/toc/1475-6366 | |
| 787 | 0 | |n https://doaj.org/toc/1475-6374 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ae3a3224d3d242d68f95da0ad4e3d80d |z Connect to this object online. |