Benzimidazole derivatives endowed with potent antileishmanial activity

• Main Authors: Michele Tonelli (Author), Elena Gabriele (Author), Francesca Piazza (Author), Nicoletta Basilico (Author), Silvia Parapini (Author), Bruno Tasso (Author), Roberta Loddo (Author), Fabio Sparatore (Author), Anna Sparatore (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two sets of benzimidazole derivatives were synthesised and tested in vitro for activity against promastigotes of Leishmania tropica and L. infantum. Most of the tested compounds resulted active against both Leishmania species, with IC50 values in the low micromolar/sub-micromolar range. Among the se...