Enhancing arginase 2 expression using target site blockers as a strategy to modulate macrophage phenotype

• Main Authors: Chiara De Santi (Author), Frances K. Nally (Author), Remsha Afzal (Author), Conor P. Duffy (Author), Stephen Fitzsimons (Author), Stephanie L. Annett (Author), Tracy Robson (Author), Jennifer K. Dowling (Author), Sally-Ann Cryan (Author), Claire E. McCoy (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macrophages are plastic cells playing a crucial role in innate immunity. While fundamental in responding to infections, when persistently maintained in a pro-inflammatory state they can initiate and sustain inflammatory diseases. Therefore, a strategy that reprograms pro-inflammatory macrophages tow...