5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumourigenesis

• Main Authors: Dieter eSteinhilber (Author), Astrid Stefanie Fischer (Author), Julia eMetzner (Author), Svenja Dorothea Steinbrink (Author), Jessica eRoos (Author), Martin eRuthardt (Author), Thorsten Jürgen Maier (Author)
• Format: Book
• Published: Frontiers Media S.A., 2010-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leukotrienes (LTs) constitute a group of bioactive lipids generated by the 5-lipoxygenase (5-LO) pathway. An increasing body of evidence supports an acute role for 5-LO products already during the earliest stages of pancreatic, prostate and colorectal carcinogenesis. First, several independent studi...