Link of sorafenib resistance with the tumor microenvironment in hepatocellular carcinoma: Mechanistic insights

• मुख्य लेखकों: Xinchen Tian (लेखक), Tinghao Yan (लेखक), Fen Liu (लेखक), Qingbin Liu (लेखक), Jing Zhao (लेखक), Huabao Xiong (लेखक), Shulong Jiang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Sorafenib, a multi-kinase inhibitor with antiangiogenic, antiproliferative, and proapoptotic properties, is the first-line treatment for patients with late-stage hepatocellular carcinoma (HCC). However, the therapeutic effect remains limited due to sorafenib resistance. Only about 30% of HCC patient...