Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

• Main Authors: Ashok Aspatwar (Author), Nanda Kumar Parvathaneni (Author), Harlan Barker (Author), Emilie Anduran (Author), Claudiu T. Supuran (Author), Ludwig Dubois (Author), Philippe Lambin (Author), Seppo Parkkila (Author), Jean-Yves Winum (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With the aim to obtain novel compounds possessing both strong affinity against human carbonic anhydrases and low toxicity, we synthesised novel thiourea and sulphonamide derivatives 3, 4 and 10, and studied their in vitro inhibitory properties against human CA I, CA II and CA IX. We also evaluated t...