Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

• Main Authors: Julie Piccand (Author), Constance Vagne (Author), Florence Blot (Author), Aline Meunier (Author), Anthony Beucher (Author), Perrine Strasser (Author), Mari L. Lund (Author), Sabitri Ghimire (Author), Laure Nivlet (Author), Céline Lapp (Author), Natalia Petersen (Author), Maja S. Engelstoft (Author), Christelle Thibault-Carpentier (Author), Céline Keime (Author), Sara Jimenez Correa (Author), Valérie Schreiber (Author), Nacho Molina (Author), Thue W. Schwartz (Author), Adèle De Arcangelis (Author), Gérard Gradwohl (Author)
• Format: Book
• Published: Elsevier, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage. Our goal is to decipher the gene regulatory networks controlling EECs specification from enteroendocrine progenit...