STIM Proteins and Orai Ca2+ Channels Are Involved in the Intracellular Pathways Activated by TLQP-21 in RAW264.7 Macrophages

• Main Authors: Laura Molteni (Author), Laura Rizzi (Author), Elena Bresciani (Author), Ramona Meanti (Author), Jean-Alain Fehrentz (Author), Pascal Verdié (Author), Robert J. Omeljaniuk (Author), Giuseppe Biagini (Author), Vittorio Locatelli (Author), Antonio Torsello (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TLQP-21 is a neuropeptide which has been implicated in regulation of nociception and other relevant physiologic functions. Although recent studies identified C3a and gC1q receptors as targets for TLQP-21, its intracellular molecular mechanisms of action remain largely unidentified. Our aim was (i) t...