Population Pharmacokinetics of Intravenous Artesunate: A Pooled Analysis of Individual Data From Patients With Severe Malaria

• Main Authors: S G Zaloumis (Author), J Tarning (Author), S Krishna (Author), R N Price (Author), N J White (Author), T M E Davis (Author), J M McCaw (Author), P Olliaro (Author), R J Maude (Author), P Kremsner (Author), A Dondorp (Author), M Gomes (Author), K Barnes (Author), J A Simpson (Author)
• Format: Book
• Published: Wiley, 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There are ~660,000 deaths from severe malaria each year. Intravenous artesunate (i.v. ARS) is the first‐line treatment in adults and children. To optimize the dosing regimen of i.v. ARS, the largest pooled population pharmacokinetic study to date of the active metabolite dihydroartemisinin (DHA) was...