Bioavailability of Melatonin after Administration of an Oral Prolonged-Release Tablet and an Immediate-Release Sublingual Spray in Healthy Male Volunteers

• Main Authors: Samira Ait Abdellah (Author), Véronique Raverot (Author), Caroline Gal (Author), Isabelle Guinobert (Author), Valérie Bardot (Author), Claude Blondeau (Author), Bruno Claustrat (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The benefit of exogenous melatonin is based on its bioavailability, which depends on the galenic form, the route of administration, the dosage, and the individual absorption and rate of hepatic metabolism. Objective The objective of this study is to investigate the bioavailabilit...