Smart stimuli-responsive carrier-free nanoassembly of SN38 prodrug as efficient chemotherapeutic nanomedicine

• Main Authors: Guanting Li (Author), Qianhui Jin (Author), Fengli Xia (Author), Shuwen Fu (Author), Xuanbo Zhang (Author), Hongying Xiao (Author), Chutong Tian (Author), Qingzhi Lv (Author), Jin Sun (Author), Zhonggui He (Author), Bingjun Sun (Author)
• Format: Book
• Published: Compuscript Ltd, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The compound 7-ethyl-10-hydroxy-camptothecin (SN38) is a broad-spectrum antitumor agent whose applications are greatly limited by its poor solubility. Therefore, irinotecan, the hydrophilic derived prodrug of SN38, has been developed as the commercial formulation Campto® for colorectal cancer. Howev...