Oral delivery of carrier-free dual-drug nanocrystal self-assembled microspheres improved NAD+ bioavailability and attenuated cardiac ischemia/reperfusion injury in mice

• मुख्य लेखकों: Hongfei Nie (लेखक), Yarong Zhang (लेखक), Haiyang Yu (लेखक), Hong Xiao (लेखक), Tao Li (लेखक), Qian Yang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Nicotinamide riboside (NR), as a dietary supplement, can be converted to nicotinamide adenine dinucleotide (NAD+) in cells to support mitochondrial energy metabolism. However, the efficacy of oral administrated NR is limited due to its quick degradation in circulation and low bioavailability in targ...