Blockade of PD-L1/PD-1 signaling promotes osteo-/odontogenic differentiation through Ras activation

• Main Authors: So Mi Jeon (Author), Je Sun Lim (Author), Su Hwan Park (Author), Hyung Joon Kim (Author), Hyung-Ryong Kim (Author), Jong-Ho Lee (Author)
• Format: Book
• Published: Nature Publishing Group, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The programmed cell death ligand 1 (PD-L1) and its receptor programmed cell death 1 (PD-1) deliver inhibitory signals to regulate immunological tolerance during immune-mediated diseases. However, the role of PD-1 signaling and its blockade effect on human dental pulp stem cells (hDPSCs) dif...