Mitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation Products

• Main Authors: Giuseppina Barrera (Author), Fabrizio Gentile (Author), Stefania Pizzimenti (Author), Rosa Angela Canuto (Author), Martina Daga (Author), Alessia Arcaro (Author), Giovanni Paolo Cetrangolo (Author), Alessio Lepore (Author), Carlo Ferretti (Author), Chiara Dianzani (Author), Giuliana Muzio (Author)
• Format: Book
• Published: MDPI AG, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In several human diseases, such as cancer and neurodegenerative diseases, the levels of reactive oxygen species (ROS), produced mainly by mitochondrial oxidative phosphorylation, is increased. In cancer cells, the increase of ROS production has been associated with mtDNA mutations that, in turn, see...