Development of hepatic impairment aggravates chemotherapy-induced peripheral neuropathy following oxaliplatin treatment: Evidence from clinical and preclinical studies

• Main Authors: Tomoyoshi Miyamoto (Author), Risa Domoto (Author), Fumiko Sekiguchi (Author), Riki Kamaguchi (Author), Rika Nishimura (Author), Misato Matsuno (Author), Maho Tsubota (Author), Masanori Fujitani (Author), Shigekatsu Hatanaka (Author), Yuichi Koizumi (Author), Dengli Wang (Author), Masahiro Nishibori (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin often induces peripheral neuropathy, a dose-limiting adverse reaction, and in rare cases leads to sinusoidal obstruction syndrome. We thus conducted a retrospective cohort study to examine the relationship between oxaliplatin-induced peripheral neuropathy (OIPN) and hepatic impairment, a...