4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice

• Asıl Yazarlar: Hongqiong Zhao (Yazar), Zhihui Jiang (Yazar), Xuemei Chang (Yazar), Huiting Xue (Yazar), Wumaierjiang Yahefu (Yazar), Xiaoying Zhang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2018-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Acetaminophen (APAP) overdose is the principal cause of drug-induced acute liver failure. 4-hydroxyphenylacetic acid (4-HPA), a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. This study seeks to investigate the ability of 4-HPA to protect against APAP-in...