Diurnal Rhythmicity in the Transcription of Jejunal Drug Transporters†

• Main Authors: Adam T. Stearns (Author), Anita Balakrishnan (Author), David B. Rhoads (Author), Stanley W. Ashley (Author), Ali Tavakkolizadeh (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intestinal drug efflux proteins play a major role in the pharmacokinetics of many drugs. We assessed diurnal rhythmicity in the expression of ten major drug transporters. We acquired male Sprague-Dawley rats and harvested jejunal mucosa at 3-h intervals across a 24-h period. qPCR was performed for t...