Diurnal Rhythmicity in the Transcription of Jejunal Drug Transporters†
Intestinal drug efflux proteins play a major role in the pharmacokinetics of many drugs. We assessed diurnal rhythmicity in the expression of ten major drug transporters. We acquired male Sprague-Dawley rats and harvested jejunal mucosa at 3-h intervals across a 24-h period. qPCR was performed for t...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2008-01-01T00:00:00Z.
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