Metronomic delivery of orally available pemetrexed-incorporated colloidal dispersions for boosting tumor-specific immunity

• Main Authors: Ruby Maharjan (Author), Laxman Subedi (Author), Rudra Pangeni (Author), Saurav Kumar Jha (Author), Seo Hee Kang (Author), Kwan-Young Chang (Author), Youngro Byun (Author), Jeong Uk Choi (Author), Jin Woo Park (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we developed oral pemetrexed (PMX) for metronomic dosing to enhance antitumor immunity. PMX was electrostatically complexed with positively charged lysine-linked deoxycholic acid (DL) as an intestinal permeation enhancer, forming PMX/DL, to enhance its intestinal permeability. PMX/DL...