A "middle‐out approach" for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models

• Κύριοι συγγραφείς: Estelle Yau (Συγγραφέας), Michael Gertz (Συγγραφέας), Kayode Ogungbenro (Συγγραφέας), Leon Aarons (Συγγραφέας), Andrés Olivares‐Morales (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Wiley, 2023-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Simplified physiologically based pharmacokinetic (PBPK) models using estimated tissue‐to‐unbound plasma partition coefficients (Kpus) were previously investigated by fitting them to in vivo pharmacokinetic (PK) data. After optimization with preclinical data, the performance of these models...