Development and Optimization of a Redox Enzyme-Based Fluorescence Biosensor for the Identification of MsrB1 Inhibitors

• প্রধান লেখক: Hyun Bo Shim (লেখক), Hyunjeong Lee (লেখক), Hwa Yeon Cho (লেখক), Young Ho Jo (লেখক), Lionel Tarrago (লেখক), Hyunggee Kim (লেখক), Vadim N. Gladyshev (লেখক), Byung Cheon Lee (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2024-11-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

MsrB1 is a thiol-dependent enzyme that reduces protein methionine-<i>R</i>-sulfoxide and regulates inflammatory response in macrophages. Therefore, MsrB1 could be a promising therapeutic target for the control of inflammation. To identify MsrB1 inhibitors, we construct a redox protein-ba...