Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders

• Main Authors: Giovanna Rassu (Author), Elena Piera Porcu (Author), Silvia Fancello (Author), Antonella Obinu (Author), Nina Senes (Author), Grazia Galleri (Author), Rossana Migheli (Author), Elisabetta Gavini (Author), Paolo Giunchedi (Author)
• Format: Book
• Published: MDPI AG, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genistein has been reported to have antioxidant and neuroprotective activity. Despite encouraging in vitro and in vivo results, several disadvantages such as poor water solubility, rapid metabolism, and low oral bioavailability limit the clinical application of genistein. The aim of this study was t...