A small molecule UPR modulator for diabetes identified by high throughput screening
Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the synthesis of chaperones. In addition, UPR also...
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Elsevier,
2021-12-01T00:00:00Z.
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