A small molecule UPR modulator for diabetes identified by high throughput screening

• Main Authors: Valeria Marrocco (Author), Tuan Tran (Author), Siying Zhu (Author), Seung Hyuk Choi (Author), Ana M. Gamo (Author), Sijia Li (Author), Qiangwei Fu (Author), Marta Diez Cunado (Author), Jason Roland (Author), Mitch Hull (Author), Van Nguyen-Tran (Author), Sean Joseph (Author), Arnab K. Chatterjee (Author), Nikki Rogers (Author), Matthew S. Tremblay (Author), Weijun Shen (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the synthesis of chaperones. In addition, UPR also...