QSAR, pharmacophore modeling and molecular docking studies to identify structural alerts for some nitrogen heterocycles as dual inhibitor of telomerase reverse transcriptase and human telomeric G-quadruplex DNA

• Glavni autori: R. D. Jawarkar (Autor), R. L. Bakal (Autor), P. N. Khatale (Autor), Israa Lewaa (Autor), Chetan M. Jain (Autor), Jagdish V. Manwar (Autor), Minal S. Jaiswal (Autor)
• Format: Knjiga
• Izdano: SpringerOpen, 2021-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Background Telomerase reverse transcriptase (TERT) and human telomeric G-quadruplex DNA are amongst the favorable target for researchers to discover novel and more effective anticancer agents. To understand and elucidate structure activity relationship and mechanism of inhibition of telomer...