QSAR, pharmacophore modeling and molecular docking studies to identify structural alerts for some nitrogen heterocycles as dual inhibitor of telomerase reverse transcriptase and human telomeric G-quadruplex DNA

• Main Authors: R. D. Jawarkar (Author), R. L. Bakal (Author), P. N. Khatale (Author), Israa Lewaa (Author), Chetan M. Jain (Author), Jagdish V. Manwar (Author), Minal S. Jaiswal (Author)
• Format: Book
• Published: SpringerOpen, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Telomerase reverse transcriptase (TERT) and human telomeric G-quadruplex DNA are amongst the favorable target for researchers to discover novel and more effective anticancer agents. To understand and elucidate structure activity relationship and mechanism of inhibition of telomer...