Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis

• Main Authors: Qian Zhao (Author), Jiale Dong (Author), Han Liu (Author), Hui Chen (Author), Huan Yu (Author), Shuyin Ye (Author), Shuangjin Yu (Author), Yu Li (Author), Longhui Qiu (Author), Nazi Song (Author), Hongjiao Xu (Author), Qi Liu (Author), Zhiteng Luo (Author), Yuyi Li (Author), Rui Wang (Author), Guodong Chen (Author), Xianxing Jiang (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The role of co-agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) in chronic kidney disease (CKD) remains unclear. Herein we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compared to healthy mice and were correlated with disea...