Vincristine Promotes Transdifferentiation of Fibroblasts Into Myofibroblasts via P38 and ERK Signal Pathways

• Main Authors: Hui Xu (Author), Jingwen Yang (Author), Mengyun Tu (Author), Jie Weng (Author), Mengying Xie (Author), Zhiliang Zhou (Author), Peisen Zhou (Author), Liang Wang (Author), Chan Chen (Author), Zhiyi Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Vincristine (VCR) is used in the clinic as an anti-tumor drug. VCR can cause pulmonary fibrosis (PF), leading to respiratory failure. The transformation of fibroblasts into myofibroblasts may play a key role in PF. The present study attempted to reveal the molecular mechanism of VCR-indu...