Biomimetic device and foreign body reaction cooperate for efficient tumour cell capture in murine advanced ovarian cancer

• Main Authors: Lorena Alonso-Alconada (Author), Alexandre de la Fuente (Author), María Santacana (Author), Alba Ferreiros (Author), Rafael Lopez-Lopez (Author), Xavier Matias-Guiu (Author), Miguel Abal (Author)
• Format: Book
• Published: The Company of Biologists, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metastasis is facilitated by the formation of pre-metastatic niches through the remodelling of the extracellular matrix (ECM) promoted by haematopoietic and stromal cells. The impact of these primed sites is pronounced for intraperitoneal metastases, where the cavity-exposed ECM supports the attachm...