Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy

• Main Authors: Xiangyi Wang (Author), Jin Zhang (Author), Kailu Zheng (Author), Qianqian Du (Author), Guocai Wang (Author), Jianpeng Huang (Author), Yanhe Zhou (Author), Yan Li (Author), Hongtao Jin (Author), Jiuming He (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Against tumor-dependent metabolic vulnerability is an attractive strategy for tumor-targeted therapy. However, metabolic inhibitors are limited by the drug resistance of cancerous cells due to their metabolic plasticity and heterogeneity. Herein, choline metabolism was discovered by spatially resolv...