Transcriptomic analysis of the innate immune response to in vitro transfection of plasmid DNA

• Asıl Yazarlar: Eric Warga (Yazar), Jared Anderson (Yazar), Matthew Tucker (Yazar), Emily Harris (Yazar), Jacob Elmer (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2023-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The innate immune response to cytosolic DNA is intended to protect the host from viral infections, but it can also inhibit the delivery and expression of therapeutic transgenes in gene and cell therapies. The goal of this work was to use mRNA sequencing to identify genes that may influence transfect...