Glutamine protects against cisplatin-induced nephrotoxicity by decreasing cisplatin accumulation

• Main Authors: Hyun-Jung Kim (Author), Dong Jun Park (Author), Jin Hyun Kim (Author), Eun Young Jeong (Author), Myeong Hee Jung (Author), Tae-Ho Kim (Author), Jung Ill Yang (Author), Gyeong-Won Lee (Author), Hye Jin Chung (Author), Se-Ho Chang (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin is a chemotherapeutic drug but induces acute kidney injury (AKI). Cisplatin-induced AKI depends on several signaling pathways leading to apoptosis in tubular epithelial cells. Glutamine is a substrate for the synthesis of glutathione, the most abundant intracellular thiol and antioxidant,...