Glutamine protects against cisplatin-induced nephrotoxicity by decreasing cisplatin accumulation

• Egile Nagusiak: Hyun-Jung Kim (Egilea), Dong Jun Park (Egilea), Jin Hyun Kim (Egilea), Eun Young Jeong (Egilea), Myeong Hee Jung (Egilea), Tae-Ho Kim (Egilea), Jung Ill Yang (Egilea), Gyeong-Won Lee (Egilea), Hye Jin Chung (Egilea), Se-Ho Chang (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2015-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Cisplatin is a chemotherapeutic drug but induces acute kidney injury (AKI). Cisplatin-induced AKI depends on several signaling pathways leading to apoptosis in tubular epithelial cells. Glutamine is a substrate for the synthesis of glutathione, the most abundant intracellular thiol and antioxidant,...