Improved loss-of-function CRISPR-Cas9 genome editing in human cells concomitant with inhibition of TGF-β signaling

Improved loss-of-function CRISPR-Cas9 genome editing in human cells concomitant with inhibition of TGF-β signaling

Strategies to modulate cellular DNA repair pathways hold immense potential to enhance the efficiency of CRISPR-Cas9 genome editing platform. In the absence of a repair template, CRISPR-Cas9-induced DNA double-strand breaks are repaired by the endogenous cellular DNA repair pathways to generate loss-...

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Main Authors: Tarun Mishra (Author), Vipin Bhardwaj (Author), Neha Ahuja (Author), Pallavi Gadgil (Author), Pavitra Ramdas (Author), Sanjeev Shukla (Author), Ajit Chande (Author)
Format: Book
Published: Elsevier, 2022-06-01T00:00:00Z.
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