Dual Tumor-Targeting Nanocarrier System for siRNA Delivery Based on pRNA and Modified Chitosan

• Main Authors: Lin Li (Author), Xiaoqin Hu (Author), Min Zhang (Author), Siyu Ma (Author), Fanglin Yu (Author), Shiqing Zhao (Author), Nan Liu (Author), Zhiyuan Wang (Author), Yu Wang (Author), Hua Guan (Author), Xiujie Pan (Author), Yue Gao (Author), Yue Zhang (Author), Yan Liu (Author), Yang Yang (Author), Xuemei Tang (Author), Mingyuan Li (Author), Cheng Liu (Author), Zhiping Li (Author), Xingguo Mei (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Highly specific and efficient delivery of siRNA is still unsatisfactory. Herein, a dual tumor-targeting siRNA delivery system combining pRNA dimers with chitosan nanoparticles (CNPPs) was designed to improve the specificity and efficiency of siRNA delivery. In this dual delivery system, folate-conju...