Hyperferritinaemia in dengue virus infected patients is associated with immune activation and coagulation disturbances.

• Main Authors: Cornelia A M van de Weg (Author), Ralph M H G Huits (Author), Cláudio S Pannuti (Author), Rosalba M Brouns (Author), Riemsdijk W A van den Berg (Author), Henk-Jan van den Ham (Author), Byron E E Martina (Author), Albert D M E Osterhaus (Author), Mihai G Netea (Author), Joost C M Meijers (Author), Eric C M van Gorp (Author), Esper G Kallas (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During a dengue outbreak on the Caribbean island Aruba, highly elevated levels of ferritin were detected in dengue virus infected patients. Ferritin is an acute-phase reactant and hyperferritinaemia is a hallmark of diseases caused by extensive immune activation, such as haemophagocytic lymphohistio...