High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities

• Main Authors: Rebecca M. Parodi-Rullán (Author), Xavier Chapa-Dubocq (Author), Pedro J. Rullán (Author), Sehwan Jang (Author), Sabzali Javadov (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Sirtuins are NAD+-dependent deacetylases that regulate cell metabolism through protein acetylation/deacetylation, and SIRT3 is the major deacetylase among mitochondrial isoforms. Here, we elucidated the possible role of acetylation of cyclophilin D, a key regulator of the mitochondrial permeabi...