Allicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania.

BACKGROUND:Allicin has shown antileishmanial activity in vitro and in vivo. However the mechanism of action underlying its antiproliferative effect against Leishmania has been virtually unexplored. In this paper, we present the results obtained in L.infantum and a mechanistic basis is proposed. METH...

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Main Authors: María J Corral (Author), Elena Benito-Peña (Author), M Dolores Jiménez-Antón (Author), Laureano Cuevas (Author), María C Moreno-Bondi (Author), José M Alunda (Author)
Format: Book
Published: Public Library of Science (PLoS), 2016-03-01T00:00:00Z.
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