Allicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania.

• Main Authors: María J Corral (Author), Elena Benito-Peña (Author), M Dolores Jiménez-Antón (Author), Laureano Cuevas (Author), María C Moreno-Bondi (Author), José M Alunda (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Allicin has shown antileishmanial activity in vitro and in vivo. However the mechanism of action underlying its antiproliferative effect against Leishmania has been virtually unexplored. In this paper, we present the results obtained in L.infantum and a mechanistic basis is proposed. METH...