Attenuation of High Glucose-Induced Damage in RPE Cells through p38 MAPK Signaling Pathway Inhibition

• Main Authors: Grazia Maugeri (Author), Claudio Bucolo (Author), Filippo Drago (Author), Settimio Rossi (Author), Michelino Di Rosa (Author), Rosa Imbesi (Author), Velia D'Agata (Author), Salvatore Giunta (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to investigate the high glucose damage on human retinal pigment epithelial (RPE) cells, the role of p38 MAPK signaling pathway and how dimethyl fumarate can regulate that. We carried out in vitro studies on ARPE-19 cells exposed to physiological and high glucose (HG) conditions, to...