Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice

• Main Authors: Masahiro Hashizume (Author), Marc Mouner (Author), Joshua M. Chouteau (Author), Olena M. Gorodnya (Author), Mykhaylo V. Ruchko (Author), Glenn L. Wilson (Author), Mark N. Gillespie (Author), James C. Parker (Author)
• Format: Book
• Published: MDPI AG, 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mitochondrial targeted DNA repair enzyme, 8-oxoguanine DNA glycosylase 1, was previously reported to protect against mitochondrial DNA (mtDNA) damage and ventilator induced lung injury (VILI). In the present study we determined whether mitochondrial targeted endonuclease III (EndoIII) which clea...