Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells

• Main Authors: Minmin Qu (Author), Jia Chen (Author), Bin Xu (Author), Qinyun Shi (Author), Shujing Zhao (Author), Zhaoxia Wang (Author), Zhi Li (Author), Bo Ma (Author), Hua Xu (Author), Qinong Ye (Author), Jianwei Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemotherapy has already proven widely effective in treating cancer. Chemotherapeutic agents usually include DNA damaging agents and non-DNA damaging agents. Assessing genotoxic effect is significant during chemotherapy drug development, since the ability to attack DNA is the major concern for DNA d...