A Novel Bivalent Mannosylated Targeting Ligand Displayed on Nanoparticles Selectively Targets Anti-Inflammatory M2 Macrophages

• Main Authors: Peiming Chen (Author), Xiaoping Zhang (Author), Alessandro Venosa (Author), In Heon Lee (Author), Daniel Myers (Author), Jennifer A. Holloway (Author), Robert K. Prud'homme (Author), Dayuan Gao (Author), Zoltan Szekely (Author), Jeffery D. Laskin (Author), Debra L. Laskin (Author), Patrick J. Sinko (Author)
• Format: Book
• Published: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Persistent activation of macrophages (MP)s into a proinflammatory M1 or anti-inflammatory M2 phenotype plays a role in several pathological conditions, including autoimmune diseases, fibrosis, infections, atherosclerosis and tumor development. The mannose receptor (MR, CD206), expressed at low level...