Enhancing Oral Bioavailability of Simvastatin Using Uncoated and Polymer-Coated Solid Lipid Nanoparticles

• 主要な著者: Amira E. Abd-Elghany (著者), Omar El-Garhy (著者), Adel Al Fatease (著者), Ali H. Alamri (著者), Hamdy Abdelkader (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2024-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Simvastatin (SVA) is a well-prescribed drug for treating cardiovascular and hypercholesterolemia. Due to the extensive hepatic first-pass metabolism and poor solubility, its oral bioavailability is 5%. Solid lipid nanoparticles (SLNs) and hydrogel-coated SLNs were investigated to overcome the limite...