Cathepsin B-activatable cyclic antisense oligonucleotides for cell-specific target gene knockdown in vitro and in vivo

• Main Authors: Zhongyu Wang (Author), Xinli Fan (Author), Guanqun Mu (Author), Xiaoran Zhao (Author), Qian Wang (Author), Jing Wang (Author), Xinjing Tang (Author)
• 格式: 图书
• 出版: Elsevier, 2023-09-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Trigger-activatable antisense oligonucleotides have been widely applied to regulate gene function. Among them, caged cyclic antisense oligonucleotides (cASOs) maintain a specific topology that temporarily inhibits their interaction with target genes. By inserting linkers that respond to cell-specifi...