Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes.

A library of 426 FDA-approved drugs was screened for in vitro activity against E. multilocularis metacestodes employing the phosphoglucose isomerase (PGI) assay. Initial screening at 20 µM revealed that 7 drugs induced considerable metacestode damage, and further dose-response studies revealed that...

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Main Authors: Britta Stadelmann (Author), Denise Aeschbacher (Author), Cristina Huber (Author), Markus Spiliotis (Author), Joachim Müller (Author), Andrew Hemphill (Author)
Format: Book
Published: Public Library of Science (PLoS), 2014-12-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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