Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes.

• Auteurs principaux: Britta Stadelmann (Auteur), Denise Aeschbacher (Auteur), Cristina Huber (Auteur), Markus Spiliotis (Auteur), Joachim Müller (Auteur), Andrew Hemphill (Auteur)
• Format: Livre
• Publié: Public Library of Science (PLoS), 2014-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

A library of 426 FDA-approved drugs was screened for in vitro activity against E. multilocularis metacestodes employing the phosphoglucose isomerase (PGI) assay. Initial screening at 20 µM revealed that 7 drugs induced considerable metacestode damage, and further dose-response studies revealed that...