Suramin inhibits antibody binding to cell surface antigens and disrupts complement-mediated mesangial cell lysis

• Main Authors: Honglan Piao (Author), Yuan Chi (Author), Xiling Zhang (Author), Zhen Zhang (Author), Kun Gao (Author), Manabu Niimi (Author), Manabu Kamiyama (Author), Jinming Zhang (Author), Masayuki Takeda (Author), Jian Yao (Author)
• Format: Book
• Published: Elsevier, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Suramin inhibits immune responses and protects cells against inflammatory cell injury. However, little is known about its mechanisms. Using an in vitro model of glomerular mesangial cell (MC) lysis induced by antibodies plus complement, we investigated the potential protective effects and mechanisms...