Melatonin Protects against the Side-Effects of 5-Fluorouracil on Hippocampal Neurogenesis and Ameliorates Antioxidant Activity in an Adult Rat Hippocampus and Prefrontal Cortex

• Main Authors: Kornrawee Suwannakot (Author), Nataya Sritawan (Author), Ram Prajit (Author), Anusara Aranarochana (Author), Apiwat Sirichoat (Author), Wanassanun Pannangrong (Author), Peter Wigmore (Author), Jariya Umka Welbat (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melatonin is an endogenous hormone that exhibits antioxidant functions and neuroprotective effects. The hippocampus and the prefrontal cortex (PFC) play an important role linked to working memory. 5-fluorouracil (5-FU) can induce oxidative stress and reduce neurogenesis in the subgranular zone (SGZ)...