The emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy
ABSTRACTThe clinical development of 4-1BB agonists for cancer immunotherapy has raised substantial interest during the past decade. The first generation of 4-1BB agonistic antibodies entering the clinic, urelumab (BMS-663513) and utomilumab (PF-05082566), failed due to (liver) toxicity or lack of ef...
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Taylor & Francis Group,
2023-12-01T00:00:00Z.
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