Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity

• Main Authors: Arnaud F. Kouam (Author), Fei Yuan (Author), Frédéric N. Njayou (Author), Hongtao He (Author), Roméo F. Tsayem (Author), Babayemi O. Oladejo (Author), Fuhang Song (Author), Paul F. Moundipa (Author), George F. Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug-induced liver injury (DILI) is a major clinical problem where natural compounds hold promise for its abrogation. Khaya grandifoliola (Meliaceae) is used in Cameroonian traditional medicine for the treatment of liver related diseases and has been studied for its hepatoprotective properties. Till...