Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity

• Main Authors: Joseph L. Jilek (Author), Kayla L. Frost (Author), Kevyn A. Jacobus (Author), Wenxi He (Author), Erica L. Toth (Author), Michael Goedken (Author), Nathan J. Cherrington (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion. Alterations to renal drug transporter expression have been discovered during nonalcohol...