Mathematical Modeling of Complement Pathway Dynamics for Target Validation and Selection of Drug Modalities for Complement Therapies

• Main Authors: Loveleena Bansal (Author), Eva-Maria Nichols (Author), Daniel P. Howsmon (Author), Jessica Neisen (Author), Christina M. Bessant (Author), Fraser Cunningham (Author), Sebastien Petit-Frere (Author), Steve Ludbrook (Author), Valeriu Damian (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Motivation: The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases. Nevertheless, very few drugs that target complement proteins have made it...