Vincristine-Induced Peripheral Neuropathy in Childhood Acute Lymphoblastic Leukemia: Genetic Variation as a Potential Risk Factor

• Main Authors: Qing-Yan Yang (Author), Ya-Hui Hu (Author), Hong-Li Guo (Author), Ying Xia (Author), Yong Zhang (Author), Wei-Rong Fang (Author), Yun-Man Li (Author), Jing Xu (Author), Feng Chen (Author), Yong-Ren Wang (Author), Teng-Fei Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vincristine (VCR) is the first-line chemotherapeutic medication often co-administered with other drugs to treat childhood acute lymphoblastic leukemia. Dose-dependent neurotoxicity is the main factor restricting VCR's clinical application. VCR-induced peripheral neuropathy (VIPN) sometimes resu...